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From Interstate 70:

Take the Highway 19 South exit (#175). Go south 15 miles and cross the Missouri River bridge into Hermann. At the four-way stop, turn left on East Fourth Street. Look for the Grapevine Guest Suite at the corner of Fourth and Schiller, diagonally across from the Historic Hermann Museum.

From I-44 traveling west from St. Louis:

Take Highway 100 West exit (#251). Continue west on 100 through Washington and New Haven. In Hermann, at the Missouri River bridge, turn left on Highway 19 (Market Street). At the four-way stop, turn left on East Fourth Street. Look for the Grapevine Guest Suite at the corner of Fourth and Schiller, diagonally across from the Historic Hermann Museum.

From I-44 traveling east from Springfield:

Take the Highway 19 North exit (#208). Go north 50 miles to Hermann. Continue north on 19 (Market Street) through the Hermann business district. At the four-way stop, turn right on East Fourth Street. Look for the Grapevine Guest Suite at the corner of Fourth and Schiller, diagonally across from the Historic Hermann Museum.